Pazopanib Impurity 11 Dihydrate CAS 80927-55-5(free base)

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.80927-55-5(free base)
Molecular FormulaC4H3ClN2O
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Pazopanib Impurity 11 Dihydrate CAS 80927-55-5(free base) chemical structure

Description

Compared with other compounds in its class, the molecular weight of 148.55 g/mol gives Pazopanib Impurity 11 Dihydrate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Pazopanib Impurity 11 Dihydrate (CAS 80927-55-5(free base)), a pharmacopoeial impurity reference standard (molecular formula C4H3ClN2OH2O, MW 148.55 g/mol) used for the identification and quantification of trace impurities in APIs.

Pazopanib Impurity 11 Dihydrate (C4H3ClN2OH2O) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Pazopanib Impurity 11 Dihydrate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4H3ClN2O 2*H2O
Molecular Weight148.55 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
Halogen ContentCl-containing
Nitrogen Atoms2

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